Journal article
Increased peripheral inflammation in schizophrenia is associated with worse cognitive performance and related cortical thickness reductions
HF North, J Bruggemann, V Cropley, V Swaminathan, S Sundram, R Lenroot, AM Pereira, A Zalesky, C Bousman, C Pantelis, TW Weickert, C Shannon Weickert
European Archives of Psychiatry and Clinical Neuroscience | SPRINGER HEIDELBERG | Published : 2021
Abstract
While the biological substrates of brain and behavioural changes in persons with schizophrenia remain unclear, increasing evidence implicates that inflammation is involved. In schizophrenia, including first-episode psychosis and anti-psychotic naïve patients, there are numerous reports of increased peripheral inflammation, cognitive deficits and neuropathologies such as cortical thinning. Research defining the relationship between inflammation and schizophrenia symptomatology and neuropathology is needed. Therefore, we analysed the level of C-reactive protein (CRP), a peripheral inflammation marker, and its relationship with cognitive functioning in a cohort of 644 controls and 499 schizophr..
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Awarded by Sylvia and Charles Viertel Charitable Foundation
Funding Acknowledgements
CSW is funded by the NSW Ministry of Health, Office of Health and Medical Research. CSW is a recipient of a National Health and Medical Research Council (Australia) Principal Research Fellowship (PRF) (#1117079). CSW is on an advisory board for Lundbeck, Australia Pty Ltd and in collaboration with Astellas Pharma Inc., Japan; however, neither of these are related to this study. VC was supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (1177370). CP was supported by a NHMRC Senior Principal Research Fellowship (1105825).